Preparation of myricetin-caffeine cocrystal and its single crystal analysis
10.11665/j.issn.1000-5048.20160313
- VernacularTitle:杨梅素-咖啡因共晶的制备及其单晶结构解析
- Author:
Jiaojiao XU
1
;
Yuanfeng WEI
;
Shuai QIAN
;
Jianjun ZHANG
Author Information
1. 中国药科大学药剂学教研室
- Publication Type:Journal Article
- Keywords:
myricetin;
caffeine;
cocrystal;
single crystal;
intrinsic dissolution rate
- From:
Journal of China Pharmaceutical University
2016;47(3):324-328
- CountryChina
- Language:Chinese
-
Abstract:
Myricetin(MYR)was cocrystallized with caffeine(CAF)by suspension and the single crystal of MYR-CAF cocrystal was cultured by slow solvent evaporation. Cocrystals obtained by two different methods were the same in crystal form after characterization with X-ray diffraction. Structural analysis of single crystal of MYR-CAF showed that its crystal system and the space group were monoclinic and P21/n, respectively. In MYR-CAF cocrystal, 4′-OH in ring B and 7-OH in ring A of MYR interacted with CAF at(8)C=N and(2)C=O through hydrogen bonds. In comparison to the original MYR crystal, the intrinsic dissolution rate of MYR was significantly enhanced for about 17-fold after cocrystallization with CAF.
