Isolation and identification of anti-inflammatory constituents from Houttuynia cordata
10.11665/j.issn.1000-5048.20160308
- VernacularTitle:鱼腥草的抗炎活性成分
- Author:
Guijun XU
1
;
Zhijun LI
;
Qi WANG
;
Jiejun TAN
;
Guoshan SHI
;
Wei QI
;
Di LI
;
Youpeng WANG
Author Information
1. 黑龙江中医药大学附属第二医院
- Publication Type:Journal Article
- Keywords:
Houttuynia cordata;
phenolic glycoside;
anti-inflammatory activity;
chemical constituents;
structural identification
- From:
Journal of China Pharmaceutical University
2016;47(3):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated and purified from the ethyl acetate fraction of Houttuynia cordata by silica gel and ODS column chromatographies. The chemical structures of the compounds were identified on the basis of physicochemical properties as well as spectral data. These isolated compounds were elucidated as sequinoside L(1), a new phenolic glycoside, together with nine known compounds, including sequinoside K(2), methyl chlorogenate(3), chlorogenic acid(4), hydroquinone(5), vanillic acid(6), hyperin(7), isoquercitrin(8), quercetin(9), and quercitrin(10). In addition, the anti-inflammatory activities of compounds 1-10 were evaluated in LPS-induced RAW264. 7 macrophages. Among them, compounds 1, 2, 6 and 9 showed potent anti-inflammatory activity which was similar to that of positive control dexamethasone.
