Synthesis of the related substances of deferasirox
10.11665/j.issn.1000-5048.20160306
- VernacularTitle:地拉罗司有关物质的合成
- Author:
Yan LUO
1
;
Jinhua GU
;
Zhiteng LUO
;
Jie WU
;
Lianbao YE
Author Information
1. 广东药科大学药科学院
- Publication Type:Journal Article
- Keywords:
deferasirox;
related;
substances;
synthesis
- From:
Journal of China Pharmaceutical University
2016;47(3):288-290
- CountryChina
- Language:Chinese
-
Abstract:
To perform the quality control of deferasirox and establish its quality criterion, three related substances which were determined by analyzing the synthetic route were synthesized, and their structures were confirmed by 1H NMR and MS. These substances were 2-(2-hydroxyphenyl)-4H-benzo［1, 3-e］oxazin-4-one(A), 2-hydroxy-N-(2-hydroxyben-zoyl)-benzamide(B), and methyl-4-［3, 5-bis(2-hydroxyphenyl)- 1H- ［1, 2, 4］triazol-1-yl］-benzoate(C).
