Advances of Hedgehog pathway in tumor resistance
10.11665/j.issn.1000-5048.20160302
- VernacularTitle:Hedgehog信号通路参与肿瘤耐药机制研究的最新进展
- Author:
Shaoliang HUANG
1
;
Li ZHAO
;
Qinglong GUO
;
Yulin WU
Author Information
1. 中国药科大学江苏省肿瘤发生与干预重点实验室；天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
Hedgehog;
pathway;
tumor resistance;
target;
advance
- From:
Journal of China Pharmaceutical University
2016;47(3):259-266
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog pathway regulates the physiological process of tumor cells, including proliferation, cycle, invasion and metastasis, and maintains tumorigenesis and development. With abnomal activation of Hedgehog pathway, most tumors response poorly to chemotherapy, which is mediated by Hedgehog pathway through activation of target gene and crosstalk with other pathways. Herein, Hedgehog pathway has been an important target for reversing resistance. In this study, the Hedgehog pathway and role of Hedgehog-mediated resistance in recent years are reviewed.
