Design, synthesis and evaluation of hydrogen sulfide-releasing derivatives of ring opening 3-n-butylphthalide as novel platelet aggregation inhibitors
10.11665/j.issn.1000-5048.20160205
- VernacularTitle:硫化氢供体型丁苯酞开环衍生物的设计、合成及抗血小板活性
- Author:
Xiaoli WANG
1
;
Zhaoya WANG
;
Linna WANG
;
Hui JI
;
Yihua ZHANG
;
Jian YIN
Author Information
1. 江南大学生物工程学院糖化学与生物技术教育部重点实验室
- Publication Type:Journal Article
- Keywords:
3-n-butylphthalide hydrogen sulfide;
hydrogen sulfide donors;
synthesis;
antiplatelet aggregation activity
- From:
Journal of China Pharmaceutical University
2016;47(2):158-162
- CountryChina
- Language:Chinese
-
Abstract:
A series of hydrogen sulfide-releasing derivatives of open ring 3-n-butylphthalide(5a-5f)were designed, synthesized, and their structures were confirmed by MS and 1H NMR. The inhibitory activity of the target compounds against adenosine diphosphate(ADP)and arachidonic acid(AA)-induced platelet aggregation was evaluated in vitro by Born′s turbidimetric assay. In comparison with 3-n-butylphthalide(NBP), compound 5e possessed better antiplatelet aggregation activity. Therefore, it may be utilized as a lead compound for further investigation.
