Advances in the tumor microenvironment-responsive smart drug delivery nanosystem
10.11665/j.issn.1000-5048.20160201
- VernacularTitle:肿瘤微环境响应型智能纳米药物载体的研究进展
- Author:
Yanhong LIU
1
;
Jianping ZHOU
;
Meirong HUO
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
stimuli-responsive;
tumor microenvironment;
drug delivery nanosystem;
antitumor;
advances
- From:
Journal of China Pharmaceutical University
2016;47(2):125-133
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of nanotechnology and in-depth understanding of tumor microenvironment, stimuli-responsive smart drug delivery nanosystem based on tumor microenvironment(TME)has received extensive attention. TME-responsive smart delivery nanosystem can transport antitumor drug in circulation stably, after arriving in tumor tissue or targeted cells, the structure of nanocarriers changes under the stimuli of TME. Improved drug concentrations in targeted site significantly increase the antitumor efficiency and reduce the side effects of drugs. The stimulating factors in the TME include pH, redox potential, enzyme, reactive oxygen species(ROS), adenosine-5′-triphosphate(ATP)and so on. This review mainly gives a comprehensive overview in the latest research and new development in TME-responsive smart drug delivery nanosystems for efficient tumor therapy, mainly based on pH response type, enzyme response, reduction response, ROS response, and ATP response smart drug delivery nanosystems. Moreover, research directions in the future are pointed out in this review.
