AF-HF001-induced positive inotropic and electrocardiac effect in normal isolated rat hearts
10.11665/j.issn.1000-5048.20170110
- VernacularTitle:AF-HF001对正常大鼠离体心脏的正性肌力及心电作用
- Author:
Chunlei TANG
1
;
Bainian FENG
Author Information
1. 江南大学药学院
- Publication Type:Journal Article
- Keywords:
AF-HF001;
isolated heart;
positive inotropic;
electrocardiac effect
- From:
Journal of China Pharmaceutical University
2017;48(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
In this study, normal isolated rat heart model was adopted to investigate the inotropic and electrocardiac effect of AF-HF001 with Lanfendorff technique on the left ventricular systolic pressure(LVSP), left ventricular end diastolic pressure(LVEDP), peak rate of rise of left ventricular pressure(+dp/dtmax)and peak rate of fall of left ventricular pressure(-dp/dtmax). The results indicated that AF-HF001 could significantly enhance LVSP, LVEDP and ±dp/dtmax in a dose-dependent manner and exerted a positive inotropic effect on normal isolated rat hearts. This study also analyzed the electrocardiac effect of AF-HF001 with the electrodes located on tip of heart, ventricular free wall and aortic root. The results exhibited that AF-HF001 did not change PR, QRS, QT or HR at various concentrations, which means that AF-HF001 could safely increase cardiac contractility. This research lays a good foundation for the further study on AF-HF001 and research on structure-activity relationship of its analogs.
