Preparation and application of novel polysulfone chiral membranes for the separation of tryptophan enantiomers
10.11665/j.issn.1000-5048.20170108
- VernacularTitle:新型聚砜手性膜的制备及其在色氨酸手性拆分中的应用
- Author:
Yibing JI
1
;
Feifei DUAN
;
Dandan HAO
;
Jianqiu CHEN
Author Information
1. 中国药科大学分析化学教研室
- Publication Type:Journal Article
- Keywords:
dodecanoyl-β-cyclodextrin;
polysulfone membrane;
tryptophan enantiomers;
chiral separation
- From:
Journal of China Pharmaceutical University
2017;48(1):53-59
- CountryChina
- Language:Chinese
-
Abstract:
To preparate a novel polysulfone chiral membranes, β-cyclodextrin was functionalized with dodecanoyl chloride, and this modified β-cyclodextrin was then incorporated into polysulfone casting solution to form the dodecanoyl-β-cyclodextrin/polysulfone chiral membrane. Meanwhile, current studies have investigated the effect of adding different amount of dodecanoyl-β-cyclodextrin on the pure water flux, bovine serum albumin(BSA)rejection rate and enantioselectivity of the membranes. The morphology of the dodecanoyl-β-cyclodextrin/polysulfone chiral membrane was characterized by scanning electron microscopy(SEM). With the incorporation of dodecanoyl-β-cyclodextrin, the pore structure of the membrane changed significantly, with more finger-like pore structures appearing in the support layer. So the membrane water flux increased significantly, while the BSA rejection rate decreased. When the addition amount of dodecanoyl-β-cyclodextrin was in the range of 2% to 3. 5%, the enantiomeric excess increased with the addition of dodecanoyl-β-cyclodextrin. A complete separation of racemic tryptophan can be performed using this novel dodecanoyl-β-cyclodextrin/polysulfone chiral membrane-based separation system.
