Advances of regulatory effects of traditional Chinese medicine on NOS/NO system
10.11665/j.issn.1000-5048.20170102
- VernacularTitle:中药对一氧化氮合酶/一氧化氮系统调节作用的研究进展
- Author:
Yuwei HAN
1
;
Yuanyuan ZHANG
;
Xiuying LAI
;
Han LIU
;
Junping KOU
Author Information
1. 中国药科大学中药复方研究室，江苏省中药评价与转化重点实验室
- Publication Type:Journal Article
- Keywords:
nitric oxide synthase;
nitric oxide;
traditional Chinese medcine;
cardiovascular diseases;
nervous system diseases;
immune system diseases
- From:
Journal of China Pharmaceutical University
2017;48(1):8-15
- CountryChina
- Language:Chinese
-
Abstract:
Nitric oxide(NO)is a vital signal messenger in human and generated by nitric oxide synthase including endothelial nitric oxide synthase(eNOS), inducible nitric oxide synthase(iNOS)and neuropathic nitric oxide synthase(nNOS). NO has important regulatory function on the immune system, nervous system and many other physiological systems. Endogenous NO can enhance the function of the vascular system and endothelial cell survival, and inhibit platelet accumulation and leukocyte infiltration. Excessive production of NO may damage tissues by cytotoxic and cytostatic effects. Thus, NO plays a dual role in physiology and pathology. This paper gives a brief review on regulatory effects of NOS-NO system by traditional Chinese medicine during the recent five years, so as to provide some clues or references for the treatment of related diseases and scientific evidene for reasonable and effective clinical application.
