Advances in the research of long-acting strategy of insulin and GLP-1 analogs

VernacularTitle:胰岛素和GLP-1类似物长效化策略研究的最新进展
Author: Chengye LI ¹ ; Wenlong HUANG ; Hai QIAN
Author Information

1. 中国药科大学新药研究中心
Publication Type:Journal Article
Keywords: insulin analogs; GLP-1 analogs; long-acting; diabetes
From: Journal of China Pharmaceutical University 2018;49(6):660-670
CountryChina
Language:Chinese
Abstract: Insulin as well as glucagon-like peptide 1(GLP-1)and its analogs are commonly used in treating type II diabetes. Both insulin and GLP-1 are endogenous peptides, and have advantages such as high efficiency and selectivity. However, there are some disadvantages to using regular insulin with slow effect, short-time effect and risk of hypoglycemia. Due to the elimination of kidneys and the metabolism of enzymes, the half-life of GLP-1 is so short that neither of them can stabilize glucose. Therefore, it is of great significance to study the long-acting strategy of insulin and GLP-1. Based on the long-acting strategy and pharmacological assessment of peptide drugs, this paper reviewed the latest progress of the related drugs that already on the market and under research to provide references for the design of novel long-acting insulin and GLP-1 analogs.