Improved synthesis of analgesic pentazocine
10.11665/j.issn.1000-5048.20180508
- VernacularTitle:镇痛药喷他佐辛的合成工艺改进
- Author:
Li LIU
1
;
Chen WANG
;
Lixin LIU
;
Tingting JI
Author Information
1. 安徽医学高等专科学校
- Publication Type:Journal Article
- Keywords:
pentazocine;
improved synthesis;
one-pot synthesis
- From:
Journal of China Pharmaceutical University
2018;49(5):568-571
- CountryChina
- Language:Chinese
-
Abstract:
A new synthetic process of pentazocine has been developed. Starting from 3, 4-dimethylpyridin and benzyl chloride, via quaternarization, Grignard reaction addition/reduction/salt, cyclization, hydrogenation, alkylation and recrystallization, pentazocine were obtained in a total yield of 8. 4%(with a molar mass of 3, 4-dimethylpyridin), with purity greater than 99. 97%. The improved synthetic route is suitable for industrial production.
