Asymmetric hydrogenation of methyl-2-acylamino-3-arylacrylate
10.11665/j.issn.1000-5048.20180506
- VernacularTitle:2-酰氨基-3-芳基丙烯酸甲酯的不对称氢化反应
- Author:
Haitao CHEN
1
;
Xiaofei LU
;
Fujiao HAN
;
Wenxin WANG
;
Jingguo FU
;
Hui CHEN
Author Information
1. 河南省科学院化学研究所有限公司
- Publication Type:Journal Article
- Keywords:
methyl-2-acylamino-3-arylacrylate;
asymmetric hydrogenation;
protective group;
D-phenylalanine
- From:
Journal of China Pharmaceutical University
2018;49(5):553-557
- CountryChina
- Language:Chinese
-
Abstract:
By using(S)-MonoPHOS and ［Rh(COD)2］BF4 as catalyst, the asymmetric hydrogenation reactions of methyl-2-acylamino-3-arylacrylate and the effect of different amino protective groups on hydrogenation efficacy were studied. The products resulting from asymmetric hydrogenation were hydrolyzed by hydrochloric acid, and the corresponding amino acids were obtained at yields of 63%- 92%.
