Applications of nuclear magnetic resonance spectroscopy in the screening of new psychoactive substances
10.11665/j.issn.1000-5048.20180505
- VernacularTitle:核磁共振技术在新精神活性物质筛查中的应用
- Author:
Jiaqi LUAN
1
;
Wei JIA
;
Zhendong HUA
;
Peng XU
;
Mengxiang SU
;
Youmei WANG
;
Bin DI
Author Information
1. 中国药科大学药学院
- Publication Type:Journal Article
- Keywords:
new psychoactive substances;
nuclear magnetic resonance spectroscopy;
synthetic cannabinoids;
synthetic cathinones;
piperazines;
phenethylamines;
ketamine & phencyclidine-type substances;
fentanyls
- From:
Journal of China Pharmaceutical University
2018;49(5):545-552
- CountryChina
- Language:Chinese
-
Abstract:
GC-MS and LC-MS are the main techniques used for the structural identification of new psychoactive substances at present. However, they are hard to give accurate structure information because of the hardly available corresponding reference standards and the quickly changing status of these compounds. This leads tremendous obstacle on the rapid identification of new psychoactive substances. Nuclear magnetic resonance spectroscopy is one of the most effective methods for structures identification. Therefore, NMR is especially suitable for the analysis and identification of new psychoactive substances even with rapid structural changes. This article summarizes the NMR applications for the structural analysis of new psychoactive substances including synthetic cannabinoids, synthetic cathinones, piperazines, phenethylamines, ketamine & phencyclidine-type substances, and fentanyls. It is found that the NMR signals of the main frame structure of each kind of the new psychoactive substances are basically the same. Hence, these frame structure NMR signals can provide scientific evidence for the rapid identification of new psychoactive substances. This article also look ahead the prospect for the application of LC-NMR and DOSY in new psychoactive substances, which provides new ideas for the screening of new psychoactive substances.
