Research advances in susceptibility genes of non-alcoholic fatty liver disease and its association with type 2 diabetes

VernacularTitle:非酒精性脂肪肝病的易感基因及与2型糖尿病相关性的研究进展
Author: Te DU ¹ ; Jing CHEN ; Xu SHEN
Author Information

1. 中国科学院上海药物研究所；中国科学院大学
Publication Type:Journal Article
Keywords: nonalcoholic fatty liver disease; type 2 diabetes mellitus; susceptibility genes; correlation
From: Journal of China Pharmaceutical University 2018;49(5):537-544
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease(NAFLD)as the most common hepatic disease worldwide is affected not only by extrinsic factors, but also by genetic ones. Type 2 diabetes mellitus(T2DM), another chronic disease regulated by both environmental and genetic factors, is closely related to NAFLD in signal pathways and susceptibility genes. This review summarizes the susceptibility genes of NAFLD, especially points out their relevance to T2DM and suggests their related clinical applications, which provide further evidence for the exploration of the mechanisms of the two diseases with a new direction for their diagnosis and treatment.