Two Cases of Autoimmnune Hepatitis Associated with Systemic Lupus Erythematosus.
- Author:
Jang Uk YOON
1
;
Sang Hoon PARK
;
Eun Jung KIM
;
Ji Hyun HONG
;
Hyung Seok LEE
;
Kil Chan OH
;
Chul Hee PARK
;
Tae Ho HAHN
;
Dong Keun LEE
;
Jong Hyeok KIM
;
Hae Lim PARK
;
Choong Kee PARK
Author Information
1. Department of Internal Medicine, Hallym University, College of Medicine, Anyang, Korea. sanghoon@hallym.or.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Hepatitis/Autoimmune;
Lupus erythematosus/Systemic
- MeSH:
Adult;
Female;
Hepatitis, Autoimmune/*complications/diagnosis;
Humans;
Lupus Erythematosus, Systemic/*complications/diagnosis;
Middle Aged
- From:The Korean Journal of Hepatology
2003;9(3):231-235
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disease of unknown cause associated with circulating autoantibodies and high serum globulin level. Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complex, affecting multiple organs including the liver, kidney, and CNS. The difference between the hepatic involvement of SLE and autoimmune hepatitis has not been clearly defined in the past due to similarities in clinical and biochemical features. A scoring system for the diagnosis of AIH has been established, and AIH and SLE-associated hepatitis have been defined as two different entities, although both have the same autoimmune features such as polyarthralgia, hypergammaglobulinemia and circulating autoantibodies. AIH has been considered to occur infrequently in SLE. We report two cases of AIH which simultaneously satisfied the criteria of SLE.
