Analysis of false-negative results for 2019 novel coronavirus nucleic acid test and related countermeasures
10.3760/cma.j.issn.1009-9158.2010.0006
- VernacularTitle: 新型冠状病毒（2019-nCoV）核酸检测假阴性结果原因分析及对策
- Author:
Jin LI
1
;
Guangming YE
1
;
Liangjun CHEN
1
;
Jiajun WANG
1
;
Yirong LI
1
Author Information
1. Department of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
- Publication Type:Journal Article
- Keywords:
Coronavirus;
Nucleic acids;
Polymerase chain reaction;
False negative reactions;
Quality control
- From:
Chinese Journal of Laboratory Medicine
2020;43(0):E006-E006
- CountryChina
- Language:Chinese
-
Abstract:
In December 2019, a cluster of patients with pneumonia of unknown cause were linked to a seafood wholesale market in Wuhan, China. Some studies found that the virus was a new kind of virus which had never been found in the human body. Then, the virus was named 2019 Novel Coronavirus (2019-nCoV) by the World Health Organization (WHO). 2019-nCoV nucleic acid detection is one of the essential indicators of NCP (Novel Coronavirus Pneumonia). Recently, some false-negative cases in China-Japan Friendship Hospital and Hangzhou Hospital led the clinical doctors to question the value of the nucleic acid detection. In this paper, more than 3 000 results of 2019-nCoV detection in Zhongnan Hospital, Wuhan University were analyzed. Attention should be paid to the root cause of false-negative results and the related countermeasures should be taken.
