Advance in research of beta coronavirus receptors on ocular surface
10.3760/cma.j.cn115989-20200223-00098
- VernacularTitle: 眼表β属冠状病毒受体的研究进展
- Author:
Xiaolei YIN
1
;
Jinping ZHANG
2
Author Information
1. Department of Ophthalmology, 305 Hospital of PLA, Beijing 100017, China
2. Novel Coronavirus Research Group in 305 Hospital of PLA, Beijing 100017,China
- Publication Type:Review
- Keywords:
Coronavirus;
Receptor;
Angiotensin-converting enzyme 2;
Dipeptidyl peptidase 4;
Ocular surface
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(0):E009-E009
- CountryChina
- Language:Chinese
-
Abstract:
Novel coronavirus (2019-nCoV) caused an outbreak of corona virus disease 2019 (COVID-19) from December 2019 in China. 2019-nCoV which was identified is a kind of beta coronavirus belongs to one of four coronavirus genera. Except 2019-nCoV, two other beta coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are also quite harmful to human beings. 2019-nCoV uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. And dipeptidyl peptidase 4 (DPP4) or CD26 is the cell receptor for MERS-CoV. The expression of ACE2 was found to have obvious positive expression in human corneal and conjunctival epithelium, and corneal endothelium. DPP4 activity was presented in normal animal conjunctival epithelium and fibroblasts of the subjacent connective tissue. It was also presented in the whole corneal epithelium and tear fluid of animal with severe injured corneas. The two receptors, ACE2 and DPP4, involve in many cellular signaling pathways and pathophysiological processes. Their expression in the cells of ocular surface may be an access route of corona virus in eye, which provides clues to elucidating the pathogenesis of corona virus in the eyeballs.
