Transitional Cell Tumor Culture and Chemosensitivity Test: Preliminary Report.
- Author:
Nack Gyeu CHOI
1
;
Kyu Man LEE
Author Information
1. Department of Urology, Hallym University, College of Medicine, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
transitional cell carcinoma;
chemosensitivity
- MeSH:
Animals;
Carcinoma, Transitional Cell;
Cells, Cultured;
Cytarabine;
Daunorubicin;
Methotrexate;
Neoplastic Stem Cells
- From:Korean Journal of Urology
1989;30(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Usually, tumor stem cells have been assessed functionally in animals with various in vivo transplantation assays or with in vitro colony forming assays. Such studies indicate the tumor stem cell assays can be used to study the properties of tumor stem cells and to delineate the difference in individual sensitivities to chemotherapeutic agents. Over the past year (1987,5-1988,4) we attempted to culture the epithelial tumor cells in laboratory to test the chemosensitivity to Methotrexate, cytarabine, and daunorubicin in different concentrations. The in vitro chemosensitivity of these cells to anticancer drugs was disappointed in much. Only 14% of the cultured cells were inhibited the growth more than 50% in over-all.
