Effect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients
10.5223/pghn.2020.23.2.132
- Author:
Eyal ZIFMAN
1
;
Noam ZEVIT
;
Merav HESHIN-BEKENSTEIN
;
Dan TURNER
;
Raanan SHAMIR
;
Ari SILBERMINTZ
Author Information
1. Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel. drzifman@gmail.com
- Publication Type:Original Article
- Keywords:
Antibodies;
Immunization;
Serology;
Child
- MeSH:
Antibodies;
Celiac Disease;
Child;
Diet, Gluten-Free;
Glutens;
Hepatitis B virus;
Hepatitis B;
Hepatitis;
Humans;
Immunization;
Infant;
Retrospective Studies;
Sex Characteristics
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2020;23(2):132-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects.METHODS: We retrospectively evaluated pediatric CD subjects in serological remission who were previously immunized for hepatitis B virus as infants. The temporal relationship between HBsAb concentration, the amount of time on a GFD, and age were evaluated.RESULTS: Overall, 373 CD subjects were analyzed: 156 with HBsAb sampled prior to GFD initiation and 217 after initiation of a GFD and in serological remission. Median age at HBsAb concentration measurement for those before and after GFD initiation was 5.3 years (interquartile range [IQR], 3.1–9.2 years) and 7.6 years (IQR, 5.4–10.9 years), respectively (p<0.001). There was no sex difference between the groups. The median time of HBsAb measurement was 2 months (IQR, 0–5.7 months) before and 12.8 months (IQR, 5.3–30.3 months) after initiation of GFD. The HBsAb concentration was low in 79 (50.6%) and 121 (55.7%) subjects before and after GFD initiation, respectively (p=0.350). Age was inversely associated with low HBsAb concentrations. Neither being on a GFD nor sex was associated with low HBsAb concentrations.CONCLUSION: Adherence to a GFD does not affect HBsAb concentration in children with CD. Age is inversely associated with HBsAb concentration.
