Comparison of safety and analgesic efficacy of diclofenac sodium with etodolac after surgical extraction of third molars: a randomized, double-blind, double-dummy, parallel-group study
10.17245/jdapm.2020.20.1.19
- Author:
Jitendra H VAGHELA
1
;
Jigna H SHAH
;
Jaladhi H PATEL
;
Bhargav M PUROHIT
Author Information
1. Department of Pharmacology, NAMO Medical College & Research Institute, Silvassa, Dadra and Nagar Haveli, India.
- Publication Type:Original Article
- From:Journal of Dental Anesthesia and Pain Medicine
2020;20(1):19-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually moderate to severe in the first 12 h postoperatively and lasts for 3–5 days. However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies.
METHODS:We compared the safety and analgesic efficacy of diclofenac sodium with etodolac peroral after surgical extraction of third molars in a double-blind, double-dummy, parallel-group study. The subjective pain improvement and pain relief after 2, 6, 24, 48, and 72 h using the visual analogue scale were measured as the study outcome.
RESULTS:Etodolac was equivalent to diclofenac sodium in pain alleviation at all postoperative time periods. No significant differences were found between diclofenac sodium and etodolac groups (P > 0.05). Both study medications were well tolerated and safe with mild adverse effects in only a few participants.
CONCLUSION:Diclofenac sodium and etodolac are comparable in terms of analgesic efficacy and safety after surgical removal of third molars.
