IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
- Author:
Da Sol KUEN
1
;
Byung Seok KIM
;
Yeonseok CHUNG
Author Information
- Publication Type:Review
- Keywords: Tumor microenvironment; Th17 cells; Interleukin-17; T-lymphocytes
- MeSH: Animals; Autoimmunity; Child; Child, Orphaned; Friends; Humans; Inflammation; Interleukin-17; Killer Cells, Natural; Lymphocytes; Mice; T-Lymphocytes; Th17 Cells; Tumor Microenvironment
- From:Immune Network 2020;20(1):6-
- CountryRepublic of Korea
- Language:English
- Abstract: IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8⁺ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.
