Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
- Author:
Yun Kyung JEON
1
;
Sang Soo KIM
;
Jong Ho KIM
;
Hyun Jeong KIM
;
Hyun Jun KIM
;
Jang Jun PARK
;
Yuen Suk CHO
;
So Hee JOUNG
;
Ji Ryang KIM
;
Bo Hyun KIM
;
Sang Heon SONG
;
In Joo KIM
;
Yong Ki KIM
;
Young Bum KIM
Author Information
- Publication Type:Original Article
- Keywords: Apolipoprotein J; Exercise; Insulin resistance; Sarcopenia
- MeSH: Adipose Tissue; Apolipoproteins; Body Composition; Body Weight; Clusterin; Diabetes Mellitus, Type 2; Exercise; Female; Humans; Insulin Resistance; Insulin; Muscle, Skeletal; Sarcopenia
- From:Diabetes & Metabolism Journal 2020;44(1):103-112
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus.METHODS: Postmenopausal women with type 2 diabetes mellitus were randomly assigned into either an exercise (EXE, n=30) or control (CON, n=15) group. Participants in the EXE group were enrolled in a 12-week program consisting of a combination of aerobic and resistance exercises. At baseline, 4, 8, and 12 weeks, body composition and metabolic parameters including homeostatic model assessment of insulin resistance (HOMA-IR) and serum ApoJ levels were assessed.RESULTS: In the EXE group, ApoJ levels decreased 26.3% and 19.4%, relative to baseline, at 8 and 12 weeks, respectively. Between-group differences were significant at 8 and 12 weeks (P<0.05 and P<0.001, respectively). In the EXE group, 12 weeks of exercise resulted in significant decreases in body weight, percent body fat, and HOMA-IR indices. Concurrently, weight-adjusted appendicular skeletal muscle mass (ASM/wt) was increased in the EXE group compared with the CON group. Importantly, changes in the ApoJ level were significantly correlated with changes in ASM/wt.CONCLUSION: Exercise training resulted in a significant decrease in the circulating ApoJ level, with changes in ApoJ associated with an improvement in some insulin resistance indices. These data suggest that circulating ApoJ may be a useful metabolic marker for assessing the effects of exercise on insulin resistance.
