A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model
- Author:
Inwon PARK
1
;
Sujung HONG
;
Yoonha HWANG
;
Pilhan KIM
Author Information
- Publication Type:Brief Communication
- From:Diabetes & Metabolism Journal 2020;44(1):193-198
- CountryRepublic of Korea
- Language:English
- Abstract: Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized cellular-level observation of the islets in the pancreas in vivo. By spatially separating the pancreas from the bowel movement and physiologic respiration with a metal plate integrated in the imaging window, we successfully tracked the pancreatic islets up to three weeks and visualized the dumbbell-shape transformation from the single islet. This window can be a useful tool for long-term cellular-level visualization of the microstructure in the pancreas.
