Investigation for the Effect of jingizai on Long-term Prognosis and Differences Between Histopathological types in 139 Cases of Ovarian Cancer
- VernacularTitle:卵巣癌139症例の長期予後と病理組織型別予後に対する参耆剤の影響
- Author:
Shinichi YAMAMOTO
1
;
Ayako OSAFUNE
1
;
Junko MATSUI
1
;
Keita NAKANE
2
;
Shohei IKEDA
2
Author Information
- Keywords: ovarian cancer; jingizai (参耆剤); long-term prognosis; histopathological type; advanced stage
- From:Kampo Medicine 2019;70(4):376-383
- CountryJapan
- Language:Japanese
- Abstract: Using the data of 139 ovarian cancer cases at our hospital, we investigated the effect of jingizai on prognosis when it was combined with standard therapy for ovarian cancer and prognosis by histopathological types. Combining jingizai with standard therapy was not effective in cases of stage I-II ovarian cancer, but it was effective in cases of stage III-IV ovarian cancer. Upon examination the effectiveness of jingizai according to histopathological types, we observed some improved prognosis in serous adenocarcinoma and mucinous adenocarcinoma cases ; however, prognosis didn't improve in endometrioid adenocarcinoma and clear cell adenocarcinoma. These results indicate that the effectiveness of combining jingizai with standard therapy may differ depending on histological type of ovarian cancer. When we investigated the difference between the distribution of histopathological types by cancer staging, we frequently found clear cell adenocarcinoma in stage I-II cancer cases. Also, serous adenocarcinoma and poorly differentiated adenocarcinoma had a high frequency among stage III-IV cancer cases. This difference may be the reason that the effectiveness of jingizai is different depending on the advances of each stage. However, no statistical difference was confirmed due to the small number of subjects analyzed. Analysis of larger sample size, which can be collected by performing collaborative studies with other facilities, will be required for more detailed investigation.
