The Decocting Time and the Contents of the Aconitine-type Diester Alkaloids in the Decoctions of the Formula Containing Unprocessed Aconite Root in “Songban Shanghanlun”

Tsukasa Fueki; Yohei Tanimura; Koichiro Tanaka; Koki Chiba; Takanori Matsuoka; Takao Namiki; Kosuke Fujita; Takao Sunaga; Masashi Beppu; Toshiaki Makino

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The Decocting Time and the Contents of the Aconitine-type Diester Alkaloids in the Decoctions of the Formula Containing Unprocessed Aconite Root in “Songban Shanghanlun”

VernacularTitle:『宋板傷寒論』の未修治附子配合処方の煎煮時間と煎液に含まれるアコニチン型ジエステルアルカロイド量
Author: Tsukasa FUEKI ¹ ; Yohei TANIMURA ² ; Koichiro TANAKA ³ ; Koki CHIBA ² ; Takanori MATSUOKA ² ; Takao NAMIKI ² ; Kosuke FUJITA ⁴ ; Takao SUNAGA ⁵ ; Masashi BEPPU ⁶ ; Toshiaki MAKINO ⁷
Author Information

1. Matsuya Pharmacy
2. Department of Traditional Medicine, Toho University School of Medicine
3. Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University
4. Public Interest Corporation Kenikai
5. Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University
6. Towa BUND Medical Cente
7. Kido Clinic
Keywords: Shanghanlun; decoction; unprocessed aconite root; aconitine-type diester alkaloids; co-decocted crude drugs
From:Kampo Medicine 2019;70(4):313-323
CountryJapan
Language:Japanese
Abstract: We investigated the decocting time to prepare the formulas containing unprocessed aconite root, such as shigyakuto, tsumyaku shigyakuto, and kankyobushito, which had been registered in “Shanghanlun” edited in Song Dynasty, using the weights and measures in Houhan Dynasty when the original “Shanghanlun” was regarded to have been established. Also the contents of aconitine-type diester alkaloids (ADA) eluted from unprocessed aconite root in the decoction were analyzed in time-dependent manners. As regards the modified formula for the “physically strong patients” in the texts of tsumyakushigyakuto in “Shanghanlun”, adding dried ginger was found to lead the decocting time to be shorter and the sum of ADA content in the decoction of the modified formula to increase about 20%. It was also found that the compositions of diterpene alkaloids derived from aconite root in kankyobushito decoction were highly different from those in shigyakuto decoction, containing less ADA and more aconine and hypaconine, due to the high pH of the decoction, which was the consequence of lacking glycyrrhiza in kankyobushito formula. It is suggested that the doctors in the era of “Shanghanlun” establishment may have carefully adjusted the contents of ADA in the decoctions using unprocessed aconite root by choosing co-decocted crude drugs.