False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases
- Author:
Dasheng LI
1
;
Dawei WANG
;
Jianping DONG
;
Nana WANG
;
He HUANG
;
Haiwang XU
;
Chen XIA
Author Information
- Publication Type:Case Report
- Keywords: COVID-19; SARS-COV-2; rRT-PCR; False-negative results; Laboratory examination; Computed tomography
- From:Korean Journal of Radiology 2020;21(4):505-508
- CountryRepublic of Korea
- Language:English
- Abstract: The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.
