Investigation on immunization program coverage rate and its safety in children with tuberous sclerosis
10.3760/cma.j.issn.0578-1310.2017.01.008
- VernacularTitle: 结节性硬化症儿童免疫规划疫苗接种率及安全性的调查研究
- Author:
Yang GAO
1
;
Liping ZOU
;
Mengna ZHANG
;
Lingyu PANG
;
Yangyang WANG
;
Shufang MA
;
Lulu HUANG
Author Information
1. Department of Pediatrics, Chinese People′s Liberation Army General Hospital, Beijing 100853, China
- Publication Type:Clinical Trail
- Keywords:
Tuberous sclerosis;
Vaccination;
Vaccines
- From:
Chinese Journal of Pediatrics
2017;55(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the status of immunization of National Immunization Program (NIP) and its adverse reaction rate in children with tuberous sclerosis.
Method:Questionnaire survey was adopted to identify the vaccination coverage and its adverse events; 72 cases of children with tuberous sclerosis and 78 normal controls (healthy children completing age-appropriate NIP) admitted to Chinese People′s Liberation Army General Hospital from December 2014 to November 2015 were involved into this study.
Result:The age-appropriate NIP coverage rate of tuberous sclerosis was 36%(26/72). The coverage rate of bacillus calmette-guerin (BCG), hepatitis B vaccine 1st to 3rd doses (HepB1-3), oral poliovaccine 1st dose (OPV1), diphtheria, pertussis and tetanus 1st dose (DPT1), DPT1-3, meningococcal polysaccharide vaccine group A (MPVA), measles amd rubella vaccine/measles vaccine 1st dose (MRV/MCV1), and Japanese encephalitis vaccine 1st dose (JEV1) were 100%(72 cases), 75%(51 cases), 97%(66 cases), 91%(62 cases), 82%(56 cases), 66%(45 cases), 69%(42 cases), and 61%(37 cases) respectively. The reasons why the children did not complete the vaccination plan were that parents were concerned about vaccination-induced seizures or seizures had not been controlled. Among 72 children with TSC, the rate of adverse events or suspected adverse events after vaccination was 17% (12 cases), which was higher than the normal control children (2 cases, 3%) (χ2=8.799, P<0.05). The main adverse events were seizure events, which accounted for 92%(11 cases).
Conclusion:The age-appropriate NIP coverage rate among children with tuberous sclerosis is low. The high incidence of adverse events may be associated with a fact that there are some nervous system abnormalities in cases with tuberous sclerosis. TSC children vaccination is relatively safe, with no serious adverse events.
