Situation analysis of timing of first visit of anti-mitochondrial antibody-positive patients
10.3760/cma.j.issn.1007-3418.2019.08.011
- VernacularTitle: 抗线粒体抗体阳性患者首次就诊情况分析
- Author:
Rui JIN
1
;
Xiaoxiao WANG
1
;
Lihua WANG
2
;
Songlin HONG
3
;
Haiyun BAI
3
;
Qing WANG
3
;
Hui MA
1
;
Jilian FANG
1
;
Hao WANG
1
;
Huiying RAO
1
;
Lai WEI
1
;
Bo FENG
1
Author Information
1. Peking University People’s Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, China
2. Information Center of Peking University People’s Hospital, Beijing 100044, China
3. F&E Data Technology Corp, Tianjin 300384, China
- Publication Type:Journal Article
- Keywords:
Anti-mitochondrial antibody;
Primary biliary cholangitis;
Comorbidities
- From:
Chinese Journal of Hepatology
2019;27(8):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the basic information of anti-mitochondrial antibody (anti-AMA)-positive patients after initial diagnosis, and to set groundwork for further exploring the clinical significance of AMA in various diseases.
Methods:Demographic data and related clinical information recorded through the Information System of Peking University People's Hospital from January 2013 to December 2016 were collected. Patients whose AMA and/or AMA-M2 first- tested as positive were recorded. Complications were classified according to the International Classification of Diseases.
Results:A total of 1323 AMA positive cases were discovered for the first time. Among them, 78.0% were women, and the age of initial diagnosis was 56.8 ± 16.0 years. The first three initially diagnosed departments were rheumatology and immunology (37.4%), liver Disease (15.9%) and hematology (15.9%) relevant to musculoskeletal and connective tissue diseases (45.2%), hematology and hematopoietic organs and immune diseases (30.6%) and circulatory system diseases (29.7%). There were 297 newly confirmed cases of primary biliary cholangitis (PBC); accounting for 89.2% of women, and the age of initial diagnosis was 60.1 ± 12.4 years. The top three departments of initially diagnosed as PBC were liver disease (37.7%), rheumatology (33.0%) and gastroenterology (15.2%), of which 39.7% had musculoskeletal and connective tissue diseases, 27.9% had circulatory diseases, and 24.9 % were combined with endocrine and metabolic diseases.
Conclusion:Besides PBC and other autoimmune diseases, AMA and / or AMA-M2 positivity can be observed in a variety of diseases in several clinical departments, and its clinical significance remains to be further clarified.
