Relationship between body mass index and clinicopathological characteristics and prognosis of gastric cancer patients
10.3760/cma.j.issn.0253-3766.2019.07.008
- VernacularTitle: 体质指数与胃癌患者临床病理特征和预后的关系
- Author:
Bangling HAN
1
;
Yimin WANG
;
Yingwei XUE
Author Information
1. Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
- Publication Type:Clinical Trail
- Keywords:
Gastric neoplasms;
Body mass index;
Survival analysis;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(7):527-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between body mass index (BMI) and clinicopathological characteristics and prognosis of gastric cancer patients.
Methods:The clinical data of 788 patients with advanced gastric cancer were retrospectively analyzed. According to WHO weight standard, BMI<18.5 kg/m2 was the low weight group, BMI 18.5~< 25.0 kg/m2 was the normal weight group, BMI ≥ 25.0 kg/m2 was the overweight group. The low weight group included 127 cases, the normal weight group included 540 cases and the overweight group included 121 cases. The relationship between different BMI groups and clinicopathological characteristics of patients was analyzed. Cox multivariate regression model was used to analyze the independent factor of the prognosis of patients.
Results:The average BMI of 788 patients was 21.70 kg/m2. The patients′ BMI was significantly correlated with depth of invasion, maximum diameter of tumors, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) (all P<0.05). BMI was marginally correlated with gender, age, smoking, alcohol consumption, TNM stage, lymph node metastasis and histological type (all P>0.05). Furthermore, BMI was significantly correlated with prealbumin, prognostic nutritional index, total protein, albumin and hemoglobin levels (all P<0.05). BMI was also significantly correlated with intraoperative bleeding volume, operation time, number of lymph node resection, number of lymph node metastasis and lymph node metastatic ratio (all P<0.05). The median survival time of the entire group was 35.3 months. The median survival time of patients in low weight group, normal weight group, and overweight group was 21.0 months, 26.3 months, and 31.2 months, respectively, the differences were statistically significant (P<0.001). Cox multivariate analysis showed that TNM stage, depth of tumor invasion, lymph node metastasis, PLR and BMI were independent risk factors of the prognosis of patients with gastric cancer (all P<0.05).
Conclusions:BMI is associated with the nutritional status, intraoperative blood loss, operative time, and lymph node metastatic ratio of patients with gastric cancer. BMI is an independent risk factor of the prognosis of patients with gastric cancer. The overall survival time of patients with low body weight is shorter than those of normal weight and overweight patients.
