Research progress of sentinel lymph node biopsy and regional dissection in melanoma
10.3760/cma.j.issn.0253-3766.2019.07.001
- VernacularTitle: 黑色素瘤前哨淋巴结活检和区域清扫的研究进展
- Author:
Weifeng LIU
1
;
Fajun YANG
;
Xiaohui NIU
Author Information
1. Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing 100035, China
- Publication Type:Review
- Keywords:
Melanoma;
Sentinel lymph node biopsy;
Stage;
Completion lymph node dissection
- From:
Chinese Journal of Oncology
2019;41(7):481-485
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is a malignant tumor derived from the skin and mucous membrane, the epidemiological data showed that the incidence of melanoma elevated rapidly in the last decade. Early lymph node metastasis is a distinguishing characteristic of melanoma. The assessment of regional lymph nodes is a vital factor for melanoma staging and comprehensive therapeutic strategies. The sentinel lymph node biopsy (SLNB) plays an important role in this comprehensive diagnosis and treatment system. Completion lymph node dissection (CLND) with positive sentinel lymph node was accepted by traditional theories. But it has recently been questioned via the latest global clinical trial. CLND limited the benefit for melanoma specific survival. However, SLNB is the reliable procedure for staging and prognostic evaluation of melanoma patients with positive sentinel lymph node, and CLND can significantly improve the local control and decrease the regional recurrence according to the evidence-based medicine. The authors summary the recently correlational research of SLNB and CLND in melanoma in this review.
