Research progress on the Yes-associated proteins parameters and its mechanism of action in liver diseases
10.3760/cma.j.issn.1007-3418.2019.07.020
- VernacularTitle: Yes相关蛋白参与肝脏疾病作用机制的研究进展
- Author:
Jiaen LIANG
1
,
2
,
3
;
Yan WANG
Author Information
1. Southern Medical University School of Pharmaceutical Science
2. Department of Infectious Diseases and Hepatology Unit, Southern Medical University Nanfang Hospital
3. Southern Medical University Biomedical Research Center, Guangzhou 510515, China
- Publication Type:Review
- Keywords:
Liver regeneration;
Liver cirrhosis;
Liver neoplasms;
Yes-associated protein;
Liver development
- From:
Chinese Journal of Hepatology
2019;27(7):572-576
- CountryChina
- Language:Chinese
-
Abstract:
The transcriptional coactivator Yes-associated protein (YAP) is involved in the regulation of various cellular physiological activities and plays an important role in controlling the size of tissues and organs for maintaining the homeostasis. YAP not only affects the transcriptional expression of its downstream target genes, but also interacts with multiple signaling pathways to form complex regulatory networks to perform specific biological functions. In addition to Hippo signaling pathway mediated protein phosphorylation, the regulatory mechanisms of YAP activity also takes part in multiple fields. YAP activity alteration can affect the morphological characteristics and physiological functions of liver tissue, and participate in the occurrence and development of liver diseases, such as liver fibrosis and primary liver cancer. This paper mainly discusses the close relationship between YAP and liver pathophysiology, in order to provide reference for further exploring its potential application in molecular targeted therapy of liver diseases.
