Relationship between selenium and the risk for oral cancer: a case-control study

Qing Chen; Lisong Lin; Lin Chen; Jing Lin; Yan Ding; Xiaodan Bao; Junfeng WU; Liangkun Lin; Lingjun Yan; Rui Wang; Bin Shi; Yu Qiu; Xiaoyan Zheng; Lizhen Pan; Fa Chen; Jing Wang; Lin Cai; Baochang HE; Fengqiong Liu

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Relationship between selenium and the risk for oral cancer: a case-control study

VernacularTitle: 硒元素与口腔癌发病关联的病例对照研究
Author: Qing CHEN ¹ ; Lisong LIN ² ; Lin CHEN ¹ ; Jing LIN ¹ ; Yan DING ¹ ; Xiaodan BAO ¹ ; Junfeng WU ¹ ; Liangkun LIN ¹ ; Lingjun YAN ¹ ; Rui WANG ¹ ; Bin SHI ² ; Yu QIU ² ; Xiaoyan ZHENG ² ; Lizhen PAN ² ; Fa CHEN ¹ ; Jing WANG ¹ ; Lin CAI ¹ ; Baochang HE ¹ ; Fengqiong LIU ¹
Author Information

1. Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China
2. Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
Publication Type:Clinical Trail
Keywords: Oral cancer; Selenium; Stratified analysis; Interaction
From: Chinese Journal of Epidemiology 2019;40(7):810-814
CountryChina
Language:Chinese
Abstract: Objective:To explore the relationship between selenium and the risk for oral cancer.
Methods:We performed a case-control study in 325 cases of newly diagnosed primary oral cancer from the First Affiliated Hospital of Fujian Medical University and 650 controls from the same hospital and community. Unconditional logistic regression and stratification analyses were used to explore the association between selenium and oral cancer. Adjusted OR and corresponding 95%CI were calculated. The analyses on multiple interactions between selenium and smoking or drinking status, and fruit or fish intake frequencies were conducted.
Results:The level of serum selenium was 112.42 (80.98-145.06) μg/L in the case group, which was lower than 164.85 (144.44-188.53) μg/L in control group, the difference was statistical significant (P<0.01). There was a negative correlation between serum selenium level and the risk for oral cancer regardless of smoking and drinking status, and fruits and fish intake frequencies (P<0.05). There were multiple interactions between serum selenium level and smoking or drinking status, and fruit and fish intakes.
Conclusions:The high level of serum selenium is a protective factor for the incidence of oral cancer, and serum selenium has multiple interactions with smoking or drinking status, and fruit and fish intakes. Therefore, reducing tobacco use and alcohol consumption and increasing the intakes of fruit and fish can reduce the risk for oral cancer to some extent.