Mortality and influencing factors on injecting drug users with HIV/AIDS in Guizhou province, 1996-2015
10.3760/cma.j.issn.0254-6450.2019.07.006
- VernacularTitle: 贵州省1996－2015年注射吸毒人群HIV/AIDS死亡率及其影响因素分析
- Author:
Yang CHEN
1
;
Xiaotian SONG
;
Yongming YAO
;
Lu HUANG
;
Zhu AN
;
Jun YUAN
;
Bing XIONG
;
Yuehui LIU
;
Yuqiong ZHANG
Author Information
1. Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550001, China
- Publication Type:Journal Article
- Keywords:
Injecting drug users;
HIV/AIDS;
Mortality;
Influencing factors
- From:
Chinese Journal of Epidemiology
2019;40(7):765-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the mortality and influencing factors on injecting drug users (IDUs) with HIV/AIDS, in Guizhou province, 1996-2015.
Methods:A retrospective cohort study was conducted on IDUs with HIV/AIDS that were reported through national comprehensive HIV/AIDS information system, in Guizhou province during 1996-2015. Cox proportional hazard regression model was used to analyze the influencing factors on the mortality of HIV/AIDS.
Results:A total of 3 958 cases of IDUs with HIV/AIDS were recruited in this study, with all-cause mortality rate of 44.01% (1 742/3 958) and total mortality rate of 7.80/100 person-years, respectively. The median survival time between diagnosis and death was 8.08 years. Mortality rate was 3.57/100 person-years in the group receiving antiretroviral therapy (ART). The mortality appeared to be 4.08/100 person-years in the group who were on methadone maintenance treatment (MMT). Data from the multiple regression analysis indicated that factors of gender, ethnicity, age when HIV/AIDS diagnosis was made, CD4+T lymphocyte (CD4) count at the first testing, ART and MMT were significantly associated with deaths among these people. The risk of death in females was 0.82 times (95%CI: 0.69-0.98) higher than that in males. The risk of deaths among the ethnic minority subjects was 1.39 times (95%CI: 1.21-1.60) higher than that of the Hans. The risk of death appeared to be 2.44 times higher (95%CI: 1.07-5.56) in the over-50-year of age group than in the <20 year-old group, when HIV/AIDS was diagnosed for the first time. The risk of death in CD4 ≥500/μl group in the first time was 0.27 times (95%CI: 0.22-0.32) more than CD4 <200/μl group in the firs time. The risk of death in cases who were treated with ART or MMT was 2.83 times (95%CI: 2.45-3.26) and 1.35 times (95%CI: 1.15-1.59) higher than those who did not receive any treatment, respectively.
Conclusion:Higher risks on death seemed to be related to the following factors: being male, older age at the time of diagnosis, lower CD4 at diagnosis, not on ART or MMT among the IDUs with HIV/AIDS in Guizhou province, between 1996-2015.
