A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation.
10.5468/ogs.2016.59.4.328
- Author:
Min Jung KWON
1
;
Min Jeong YUN
;
Min Kyu KIM
Author Information
1. Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Epigenesis, Genetic;
O(6)-methylguanine-DNA methyltransferase methylation;
Wolffian tumor
- MeSH:
Counseling;
Embryology;
Epigenesis, Genetic;
Epigenomics;
Female*;
Frozen Sections;
Germ-Line Mutation;
Humans;
Korea;
Laparotomy;
Methylation*;
Middle Aged;
Rare Diseases;
Wolffian Ducts
- From:Obstetrics & Gynecology Science
2016;59(4):328-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of embryology. Here, we describe the case of a 52-year-old woman with malignant FATWO. The patient underwent explorative laparotomy and surgical staging after a frozen section revealed malignancy. Detailed examination of the pathologic findings were consistent with FATWO. Counseling and further testing were provided to the patient to assess the risk of germline mutation and epigenetic change. An O-6-methylguanine-DNA methyltransferase gene methylation test was positive, and all other tests were normal. This is the first study to report a case of O-6-methylguanine-DNA methyltransferase methylation with FATWO in Korea.
