Efficacy and safety of active transfer of plaque versus provisional stenting with drug-eluting stents for the treatment of coronary bifurcation lesions
10.3760/cma.j.issn.0253-3758.2019.07.008
- VernacularTitle: 边支斑块主动转移技术治疗冠状动脉分叉病变的临床研究
- Author:
Hua SHEN
1
;
Lixia YANG
1
;
Zhijian WANG
1
;
Zheng JI
2
;
Bin LIU
3
;
Xueqi LI
4
;
Shaobin JIA
5
;
Qing YANG
6
;
Sai LYU
1
;
Yujie ZHOU
1
Author Information
1. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center For Coronary Heart Disease, Capital Medical University, Beijing 100029, China
2. Department of Cardiology, Tangshan Workers′ Hospital, Tangshan, Hebei 063000, China
3. Department of Cardiology, Second Hospital of Jilin University, Changchun 130041, China
4. Department of Cardiology, Fourth Hospital of Harbin Medical University, Harbin 150000, China
5. Department of Cardiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China
6. Department of Cardiology, Tianjin Medical University General Hospital, Tianjin 300000, China
- Publication Type:Clinical Trail
- Keywords:
Coronary artery disease;
Percutaneous coronary intervention;
Bifurcation lesion;
Active transfer of plaque
- From:
Chinese Journal of Cardiology
2019;47(7):549-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of active transfer of plaque (ATP) versus provisional stenting (PS) with drug-eluting stents (DES) for the treatment of coronary bifurcation lesions.
Methods:A total of 1 136 patients with bifurcation lesions hospitalized in 6 selected hospitals between January 2010 and January 2014 were included in this prospective observational trial, patients were divided into either ATP (n=560) or PS group (n=576) accordingly. The primary endpoint was target lesion revascularization within 1 year, and the second endpoints were all-cause death, cardiogenic death, myocardial infarction, stent thrombosis, stroke, recurrent angina within 1 year.
Results:There were no significant differences in age, sex, hypertension, diabetes, hyperlipidemia and smoking history between the two groups (P>0.05). The incidence of TIMI blood flow <3 grade in the side branch (1.6%(9/560) vs. 7.5% (43/576), P<0.01), acute occlusion of the side branch (1.3%(7/560) vs. 7.1%(41/576), P<0.01) and implanted stents of side branch (1.8%(10/560) vs. 7.8% (45/576), P<0.01) were significantly lower in the ATP group than those in the PS group. During the one year follow up, the rate of target lesion revascularization was similar between ATP group and PS group (4.6%(26/560) vs. 4.0%(23/576), P=0.66).
Conclusions:The effectiveness and safetyof ATP techniquein the patients with coronary bifurcation lesions is comparable to the PS technique. However, ATP technique is superior to PS technique on effectively reducing the incidence of implanted stents in the side branch.
