Effect of hydroxyapatite on critical-sized defect.
10.1186/s40902-016-0072-2
- Author:
Ryoe Woon KIM
1
;
Ji Hyoung KIM
;
Seong Yong MOON
Author Information
1. Graduate School of Dentistry, Chosun University, Gwangju, South Korea.
- Publication Type:Original Article
- Keywords:
Bone graft;
Hydroxyapatite;
Artificial Bone;
Xenograft;
Bovine bone
- MeSH:
Adult;
Anesthesia, General;
Animals;
Autografts;
Bone Regeneration;
Carbon;
Durapatite*;
Gyeonggi-do;
Heterografts;
Humans;
Korea;
Male;
Miners;
Osteogenesis;
Rats;
Rats, Sprague-Dawley;
Skull;
Transplants
- From:Maxillofacial Plastic and Reconstructive Surgery
2016;38(7):26-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium. METHODS: Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag. Swiss, n = 11 defects), and (3) hydroxyapatite (Bongros®, Bio@ Inc., Seongnam, Korea, n = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis. RESULTS: At 4 weeks after surgery, group 3 (42.90 ± 9.33 %) showed a significant difference (p < 0.05) compared to the control (30.50 ± 6.05 %) and group 2 (28.53 ± 8.62 %). At 8 weeks after surgery, group 1 (50.21 ± 6.23 %), group 2 (54.12 ± 10.54 %), and group 3 (50.92 ± 6.05 %) showed no significant difference in the new bone formation. CONCLUSIONS: Bongros®-HA was thought to be the available material for regenerating the new bone formation.
