Outcomes of patients treated with drug-coated balloons for de novo large coronary vessels
10.3760/cma.j.issn.0253-3758.2019.06.006
- VernacularTitle: 药物包被球囊治疗冠状动脉大血管原位病变的疗效观察
- Author:
Jing QIU
1
;
Zhanying HAN
;
Xi WANG
;
Wenjie LU
;
Liang PAN
;
Guoju SUN
;
Xiaofei QIN
;
Zhengbin WANG
;
Guanghui LIU
;
Xule WANG
;
Chunguang QIU
Author Information
1. Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Clinical Trail
- Keywords:
Coronary artery disease;
Percutaneous coronary intervention;
Drug-coated balloon;
Coronary vessels
- From:
Chinese Journal of Cardiology
2019;47(6):452-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of drug-coated balloons (DCB) for de novo large coronary vessels.
Methods:One hundred and two patients were retrospectively enrolled in this study, there were 104 lesions with the reference lumen diameter of target vessel more than 2.8 mm and patients were treated with DCB in de novo lesions during May 2015 and July 2017 in our center. Coronary artery angiography and quantitative coronary angiography were performed in 82 (80.4%) patients at follow up period ((8.1±1.7) months post procedure). The endpoints were late lumen loss (LLL) at follow up,and major adverse cardiac events (MACE) including cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) and stent or target lesion thrombosis at 12 months post procedure.
Results:Ninety-eight lesions were treated with DCB only, 6 (5.9%) bailout drug-eluting stent (DES) were used because of severe coronary dissection, 2 patients (2.0%) received revascularization driven by acute ischemic events during hospitalization. Cutting balloons and NSE balloons were used in 65.4% (68/104) and 26.0% (27/104) lesions. The lesion length was (12.57±3.58) mm and the DCB length was (19.87±4.55) mm. The late lumen loss was (0.01±0.52) mm during angiographic follow up. The TLR rate and overall MACE rate was 3.9% (4/102) and 3.9% (4/102) and there was no death,MI and target lesion thrombosis at 12 months follow up.
Conclusion:DCB treatment for de novo large coronary vessels is effective and safe.
