The prognostic significance of peripheral lymphocyte/monocyte ratio and PET-2 evaluation in adult Hodgkin’s lymphoma
10.3760/cma.j.issn.0253-2727.2019.05.005
- VernacularTitle: 外周血淋巴细胞/单核细胞比值及2个疗程后PET评价在成人霍奇金淋巴瘤中的预后意义
- Author:
Tao JIA
1
;
Huayuan ZHU
2
;
Li WANG
2
;
Jinhua LIANG
2
;
Lei CAO
2
;
Yi XIA
2
;
Jiazhu WU
2
;
Wei WU
2
;
Lei FAN
2
;
Jianyong LI
2
;
Wei XU
2
Author Information
1. Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China; Department of Hematology, the First People’s Hospital of Lianyungang, Lianyungang 222002, China
2. Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China
- Publication Type:Journal Article
- Keywords:
Lymphocyte/monocyte ratio;
Positron-emission tomography;
Hodgkin'
s lymphoma;
Prognosis
- From:
Chinese Journal of Hematology
2019;40(5):372-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic value of lymphocyte to monocyte ratio (LMR) and PET scan performed after first two cycles of chemotherapy (PET-2) in Hodgkin’s lymphoma (HL) .
Methods:The clinical data of 133 patients with HL diagnosed from January 2007 to March 2016 at the First Affiliated Hospital of Nanjing Medical University, were retrospectively analyzed. The X-tile software was used to calculate the optimal cut-off value of LMR. Kaplan-Meier method and Cox regression were used for survival analysis.
Results:The median age of 133 HL patients was 33 (18–84) years, and the male to female ratio was 1.9∶1. The optimal cut-off value of LMR was 2.5, and progression free survival (PFS) (P<0.001) and overall survival (OS) (P<0.001) were significantly lower in the LMR<2.5 group than that of LMR≥2.5. Multivariate survival analysis showed that LMR<2.5 was an independent predictor of PFS (P=0.002, HR=2.35, 95%CI 1.36–4.07) and OS (P=0.002, HR=10.36, 95%CI 2.35–45.66) in HL patients. The analysis of PET-2 from 56 HL patients showed that PET-2 positive patients had significantly poorer PFS (P=0.022) . After grouping LMR combined with PET-2, significant differences were found in PFS and OS between the three groups (P values were 0.009 and 0.012) .
Conclusion:LMR<2.5 is an independent prognostic factor for patients with HL. PET-2 combined with LMR may have better prognostic value.
