The prognostic significance of peripheral lymphocyte/monocyte ratio and PET-2 evaluation in adult Hodgkin’s lymphoma

Tao JIA; Huayuan ZHU; Li WANG; Jinhua LIANG; Lei CAO; Yi XIA; Jiazhu WU; Wei WU; Lei FAN; Jianyong LI; Wei XU

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The prognostic significance of peripheral lymphocyte/monocyte ratio and PET-2 evaluation in adult Hodgkin’s lymphoma

VernacularTitle: 外周血淋巴细胞/单核细胞比值及2个疗程后PET评价在成人霍奇金淋巴瘤中的预后意义
Author: Tao JIA ^{1
,

2} ; Huayuan ZHU ¹ ; Li WANG ¹ ; Jinhua LIANG ¹ ; Lei CAO ¹ ; Yi XIA ¹ ; Jiazhu WU ¹ ; Wei WU ¹ ; Lei FAN ¹ ; Jianyong LI ¹ ; Wei XU ¹
Author Information

1. Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China
2. Department of Hematology, the First People’s Hospital of Lianyungang, Lianyungang 222002, China
Publication Type:Journal Article
Keywords: Lymphocyte/monocyte ratio; Positron-emission tomography; Hodgkin' s lymphoma; Prognosis
From: Chinese Journal of Hematology 2019;40(5):372-377
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the prognostic value of lymphocyte to monocyte ratio (LMR) and PET scan performed after first two cycles of chemotherapy (PET-2) in Hodgkin’s lymphoma (HL) .
Methods:The clinical data of 133 patients with HL diagnosed from January 2007 to March 2016 at the First Affiliated Hospital of Nanjing Medical University, were retrospectively analyzed. The X-tile software was used to calculate the optimal cut-off value of LMR. Kaplan-Meier method and Cox regression were used for survival analysis.
Results:The median age of 133 HL patients was 33 (18–84) years, and the male to female ratio was 1.9∶1. The optimal cut-off value of LMR was 2.5, and progression free survival (PFS) (P<0.001) and overall survival (OS) (P<0.001) were significantly lower in the LMR<2.5 group than that of LMR≥2.5. Multivariate survival analysis showed that LMR<2.5 was an independent predictor of PFS (P=0.002, HR=2.35, 95%CI 1.36–4.07) and OS (P=0.002, HR=10.36, 95%CI 2.35–45.66) in HL patients. The analysis of PET-2 from 56 HL patients showed that PET-2 positive patients had significantly poorer PFS (P=0.022) . After grouping LMR combined with PET-2, significant differences were found in PFS and OS between the three groups (P values were 0.009 and 0.012) .
Conclusion:LMR<2.5 is an independent prognostic factor for patients with HL. PET-2 combined with LMR may have better prognostic value.