Research progress on the relationship between non-coding RNA and liver failure
10.3760/cma.j.issn.1007-3418.2019.05.016
- VernacularTitle: 非编码RNA与肝衰竭关系的研究进展
- Author:
Yao WANG
1
;
Luwen WANG
;
Zuojiong GONG
Author Information
1. Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Review
- Keywords:
Liver failure;
miRNA;
lncRNA
- From:
Chinese Journal of Hepatology
2019;27(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a familiar severe disease, with no good clinical early diagnostic indicators and treatment methods. Studies have shown that non-encoding RNA (ncRNA) characterized by microRNA (miRNA) and long non-coding RNA (lncRNA) can be used not only as an early diagnostic indicator of liver failure, but also play a key regulatory role in an inflammatory response to liver failure, hepatocyte death and hepatocyte regeneration. Simultaneously, the epigenetic regulation of ncRNA also participates in the initiation and progression of liver failure. This article reviews the relationship between miRNA, lncRNA, and liver failure to find new targets for the diagnosis and treatment of liver failure.
