Paediatric nodal marginal zone lymphoma: a clinicopathological study of seven cases
10.3760/cma.j.issn.0529-5807.2019.05.007
- VernacularTitle: 儿童淋巴结边缘区淋巴瘤七例临床病理学观察
- Author:
Dongyu BAI
1
;
Jianlan XIE
2
;
Yuanyuan ZHENG
2
;
Yanlin ZHANG
2
;
Dengyun MA
3
;
Xiaoge ZHOU
2
Author Information
1. Department of Pathology, Beijing Friendship Hospital Affiliated to Medical University, Beijing 100050, China (is Working on the Department of Pathology, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China)
2. Department of Pathology, Beijing Friendship Hospital Affiliated to Medical University, Beijing 100050, China
3. Department of Pathology, Qinghai Red Cross Hospital, Xining 810000, China Bai
- Publication Type:Journal Article
- Keywords:
Lymphoma, B-cell, marginal zone;
Child;
Diagnosis,differential
- From:
Chinese Journal of Pathology
2019;48(5):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pathological features and clinical manifestation of pediatric nodal marginal zone lymphoma(NMZL).
Methods:Histological morphology and immunophenotype of 7 cases of pediatric NMZL were retrospectively reviewed at Beijing Friendship Hospital Affiliated to Medical University between January 2008 to October 2018. Clonal rearrangement analysis was performed. Clinical information including patient follow-up data were analyzed.
Results:All 7 patients were male with a median age of 15 years aged from 10 to 26 years. All patients presented with only lymph node enlargement without B symptoms, including cervical lymph node (5 cases), preauricular lymph node (1 case) and retroauricular lymph node (1 case). Histologically, all cases showed irregular large follicles on the edges with widened marginal areas and intervesicular areas, and lesional cells were uniform with progressive transformation of germinal center centers along with a small amount of intrinsic lymphoid tissue. All 7 cases showed diffuse CD20 positivity both follicle and interfollicular region along with 30%-40% positivity in the interfollicular region (pathological region). Markers of other B-cell lymphomas werenot expressed. All 7 cases were positive for immunoglobulin(Ig) gene rearrangement. None of the patients showed no recurrence up on after follow-up for an average of 13 months.
Conclusions:Pediatric NMZL is a rare type of lymphoma that has a unique morphology and occurs almost exclusively in male children and young adults and often in head and neck lymph nodes. It has an excellent prognosis. Therefore, awareness of the disease with accurate diagnosis is important.
