Post-marketing observation on safety of inactivated enterovirus A71 vaccine (human diploid cell)
10.3760/cma.j.issn.0253-9624.2019.03.004
- VernacularTitle: 肠道病毒A71型灭活疫苗（人二倍体细胞）上市后安全性观察
- Author:
Lingzhi SHEN
1
;
Jian FU
;
Xuejiao PAN
;
Hui LIANG
;
Shuyun XIE
;
Zhiping CHEN
Author Information
1. Department of Immunization Program, Zhejiang Provincal Center for Disease Control and Prevention, Hangzhou 310051, China
- Publication Type:Journal Article
- Keywords:
Hand, foot and mouth disease;
Enterovirus;
Vaccines;
Enterovirus 71;
Safety
- From:
Chinese Journal of Preventive Medicine
2019;53(3):258-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the post-marketing safety of inactivated Enterovirus type 71 (EV-A71) vaccine (human diploid cell) .
Methods:A total of 20 191 healthy children aged 6 to 59 months were invited to receive 2 doses of EV-A71 vaccine in Zhejiang Province from September 2016 to December 2017. Child caregivers were followed up on the 4th or 5th day after each EV-A71 vaccination, and the incidence of local, systemic, and other adverse events within 3 days after vaccination was recorded to assess vaccine safety. Describe the differences in adverse events among children with different characteristics.
Results:A total of 32 230 doses were observed in this study, of which 20 191 and 12 039 were vaccinated for the first and the second dose, respectively; and the incidence of adverse events within 3 days was 2.045% (413 doses) and 1.611% (194 doses), respectively. After the first and the second dose, the number of systemic adverse events was the highest, 371 and 175 cases, respectively, with an incidence of 1.837% and 1.454%, respectively; the number of local adverse events was the lowest, 14 and 2 doses, respectively, with an incidence of 0.069% and 0.017%. Local adverse events occurred after vaccination were generally mild, and only 2 patients had level of 3; among the systemic adverse events, 39 patients had a fever level of 3 or higher, accounting for 8.2% of the total fever. Most of the symptoms in the local adverse events did not require treatment, only 3 cases of vaccination site rash and 2 cases of pruritus were self-purchased drugs or outpatient treatment; except for 5 cases of fever, the other symptoms were not hospitalized in the case of systemic adverse events.
Conclusion:The incidence of adverse events within 3 days after vaccination with EV-A71 vaccine was low in children, mainly systemic adverse events, and the prognosis was good.
