Advances in IgG4-related sinonasal diseases

VernacularTitle: IgG4相关性鼻腔鼻窦疾病的研究进展
Author: Yuan ZHANG ^{1
,

2} ; Yingshi PIAO ³ ; Luo ZHANG ^{1
,

2}
Author Information

1. Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China
2. Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China
3. Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China
Publication Type:Review
Keywords: IgG4 related disease; Nose; Paranasal sinuses
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2019;54(3):227-231
CountryChina
Language:Chinese
Abstract: IgG4 related disease (IgG4-RD) is an independent clinical pathological entity which is different from common chronic inflammation and other autoimmune diseases in recent years. It often appears in the form of tumor like tissue-destructive lesions and may be accompanied by the increase of concentration of serum IgG4. Histopathology is characterized by a large number of lymphocytes and plasma cells infiltration, storiform fibrosis and occlusive phlebitis. The characteristics of IgG4-RD in nose and sinuses have not been widely investigated. The aim of the present study is to review the advances in IgG4 related sinonasal diseases from four aspects including pathogenesis, clinical features, treatment and future research directions.