Etiologic surveillance and analysis of acute meningitis and encephalitis syndrome in Jinan city in 2013-2016
10.3760/cma.j.issn.0253-9624.2019.02.010
- VernacularTitle: 2013—2016年济南市哨点医院急性脑膜炎脑炎症候群病例病毒学监测分析
- Author:
Xiaojuan LIN
1
,
2
,
3
;
Guifang LIU
;
Min WANG
;
Zexin TAO
;
Suting WANG
;
Lizhi SONG
;
Li ZHANG
;
Aiqiang XU
Author Information
1. Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention
2. Academy of Preventive Medicine, Shandong University
3. Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China
- Publication Type:Journal Article
- Keywords:
Meningitis;
Encephalitis;
Sentinel surveillance;
Etiology
- From:
Chinese Journal of Preventive Medicine
2019;53(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To characterize the etiology and epidemiological characteristics of the acute meningitis and encephalitis syndrome (AMES) in Jinan city in 2013-2016.
Methods:The epidemiological data, clinical diagnosis, serum and cerebrospinal fluid (CSF) specimens were collected from 3 577 AMES cases in 6 sentinel hospitals in Jinan city in 2013-2016. Samples of all cases were made sero-diagnosis for Immunoglobulin (Ig) M antibody to Japanese encephalitis virus (JEV) and negative cases of JEV for enterovirus (EV), mumps virus (MuV) and herpes simplex virus (HSV) by enzyme-linked immunosorbent assay (ELISA). Virus isolation and molecular identification were performed. Positive rates were analyzed by Chi-square test.
Results:In 2013-2016, the positive rates of JEV, EV, MuV and HSV were 9.0% (322/3 577 cases), 22.1% (643/2 916 cases), 9.9% (289/2 916 cases), 26.9% (783/2 916), respectively. Of these, the positive rates of JEV were 32.9% (261/794), 1.2% (14/1 175), 1.0% (8/807) and 4.9% (39/801 cases); EV: 19.5% (91/466), 35.1% (342/974 cases), 15.5% (115/743) and 13.0% (95/733); MuV: 9.2% (43/466), 14.4% (140/974), 9.0% (67/743) and 5.3% (39/733). HSV: 35.4% (165/466), 38.5% (375/974), 25.7% (191/743) and 7.1% (52/733). There were significant differences in positive rates of 4 kinds of viruses in 2013-2016 (P<0.001). A total of 81 EV strains belonging to 8 serotypes were isolated from 1 020 CSF specimens. The positive rates were 4.8% (6 cases), 13.1% (55 cases), 4.1% (7 cases) and 4.2% (13 cases) from 2013 to 2016. Coxsackievirus (CV) B5, echovirus (E) 6 and E30 accounted for 46% (37 isolates), 22% (18 isolates) and 21% (17 isolates) of all strains.
Conclusion:The AMES cases in Jinan city in 2013-2016 were mainly caused by HSV, EV, MuV, JEV. CVB5, E6 and E30 were the dominant serotypes of EV associated with AMES cases in Jinan city.
