Effect of ambient fine particulate matters exposure on nasal oxidative stress level in patients with allergic rhinitis in Taiyuan city
10.3760/cma.j.issn.0253-9624.2019.01.008
- VernacularTitle: 大气PM2.5暴露对太原市过敏性鼻炎患者氧化应激水平的影响
- Author:
Yibing YANG
1
;
Xin LI
2
;
Qin WANG
1
;
Liu LIU
1
;
Chunyu XU
1
;
Zhe LIU
1
;
Na LI
1
;
Feng HAN
1
;
Yunpu LI
1
;
Dongqun XU
1
Author Information
1. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
2. Department of Otolaryngology Head and Neck Surgery, Shanxi Provincial People′s Hospital, Taiyuan 030012, China
- Publication Type:Journal Article
- Keywords:
Particulate matter;
Oxidative stress;
Rhinitis;
Anaphylaxis;
PM2.5
- From:
Chinese Journal of Preventive Medicine
2019;53(1):64-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of ambient fine particulate matters (PM2.5) exposure on nasal oxidative stress level in patients with allergic rhinitis (AR).
Methods:A panel of sixty AR patients was recruited as subjects. Four repeated measurements were carried out from June 2017 to January 2018. Nasal irrigation solution was collected and examined for malondialdehyde (MDA) and superoxide dismutase (SOD). Monitoring data of atmospheric pollutants and meteorological factors during measurement periods were also collected. Time activity pattern combined with micro-environment monitoring method was used to evaluate PM2.5 exposure. Mixed effect model was applied to analyze the relationship between PM2.5 exposure concentration and oxidative stress level.
Results:49 subjects accomplished the four repeated measurements, and the mean±SD of their age was (36.7±8.4) years old. The median of MDA and SOD in four measurement periods was 3.70, 3.70, 5.58, 6.24 nmol/ml, and 105.50, 102.50, 95.00, 96.50 U/ml. The concentration of PM2.5 exposure in four measurement periods was (40.0±2.7), (41.5±2.5), (52.3±5.9) and (74.7±4.9) μg/m3, respectively. Results of single pollutant mixed effect model analysis showed that 0-, 1-, 2-, 3-day lag concentrations of PM2.5 was significantly positively associated with MDA, about β (95%CI) estimated as 0.24 (0.17, 0.30), 0.34 (0.27, 0.41), 0.32 (0.20, 0.44) and 0.33 (0.23, 0.43), respectively. 0-, 1-, 2-day concentrations of PM2.5 was significantly negatively associated with SOD, about β (95%CI) estimated as -0.99 (-1.66, -0.31), -1.35 (-2.08, -0.62) and -0.94 (-1.80, -0.07), respectively. Multivariate analysis found that lag 1-day concentration of PM2.5 was still significantly associated with MDA and SOD after controlling for temperature, age and other influencing factors. For a 10 μg/m3 increase of PM2.5 concentration, MDA increased 0.26 (95%CI: 0.18, 0.33) nmol/ml, and SOD decreased 0.87 (95%CI: 0.21, 1.53) U/ml.
Conclusion:Our results suggested that PM2.5 exposure can aggravate the nasal oxidative stress response of AR patients.
