Incidence of depressive disorders and related independent risk factors in patients with chronic hepatitis C
10.3760/cma.j.issn.1007-3418.2019.01.008
- VernacularTitle: 慢性丙型肝炎患者抑郁症发病率及其相关独立危险因素
- Author:
Guangjun SONG
1
;
Huiying RAO
;
Yinghui GAO
;
Bo FENG
;
Lai WEI
Author Information
1. Hepatology Department, Peking University People’s Hospital, Peking University Hepatology Institute, Beijing 100044, China
- Publication Type:Journal Article
- Keywords:
Hepatitis C, chronic;
Depressive disorder;
Incidence;
Risk factors
- From:
Chinese Journal of Hepatology
2019;27(1):33-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence and related independent risk factors of depression in treatment-naïve Han ethnic Chinese patients with chronic hepatitis C.
Methods:Nine hundred and ninety-seven Han Chinese patients with confirmed chronic HCV infection were enrolled. Beck’s depression inventory scale was used to assess depression score. Patients were divided into two groups according to the score: score≥17, depression group (16.85%, 168/997); score <17, no depression group (83.15%, 829/997). Multivariate logistic regression was used to analyze independent risk factors related with the onset of depression in patients with chronic hepatitis C.
Results:There was a statistically significant difference between the two groups in terms of gender distribution, marital status, education level, income level and smoking status (P < 0.05). Independent risk factors were female [odds ratio (OR) = 3.85; 95% CI: 2.28-6.50, P = 0.001], decompensated cirrhosis [OR = 2.31; 95% CI: 1.20-4.48, P = 0.013], unmarried [OR = 2.01; 95% CI: 1.12-3.60, P = 0.019], separated [OR = 17.39; 95% CI: 1.64-184.47, P = 0.018], divorced [OR = 3.82; 95% CI: 1.36-10.74, P = 0.011], without higher education [OR = 2.04; 95% CI: 1.22-3.42, P = 0.007], low income [OR = 3.94; 95% CI: 1.38-11.28, P = 0.011], middle income [OR = 2.96; 95% CI: 1.02-8.62, P = 0.047], uninterrupted smoking [OR = 3.67; 95% CI: 2.13-6.31, P = 0.001], and previously smoked [OR = 3.33, 95% CI: 1.66-6.68, P = 0.001].
Conclusion:The incidence of depression in patients with chronic hepatitis C is relatively high. The independent risk factors related with depression include female, unmarried, separated, and divorced, without higher education, low and middle-income level, smoking and disease progression to decompensated cirrhosis, but no significant correlation between hepatitis C virus genotypes and viral load.
