Seroepidemiological investigation of hepatitis C virus in Zhejiang Province: a hospital-based study
10.3760/cma.j.issn.1007-3418.2018.12.012
- VernacularTitle: 浙江省丙型病毒性肝炎血清流行病学调查：一项基于医院的研究
- Author:
Ping CHEN
1
,
2
;
Yang ZHENG
3
;
Hainü GAO
1
;
Pengfei ZOU
1
;
Zhibo ZHOU
1
;
Yuhua GE
1
;
Shibo LI
4
;
Yiqun SHEN
5
;
Lanjuan LI
2
Author Information
1. Shu Lan(Hangzhou) Hospital, Hangzhou 310012, China
2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
3. College of Medicine, Zhejiang University, Hangzhou 310029, China
4. Zhoushan Hospital, Zhoushan 316000, China
5. Huzhou Central Hospital, Huzhou 313000, China
- Publication Type:Journal Article
- Keywords:
Hepatitis C Virus;
Hepatitis antibodies;
Zhejiang province;
Seroepidemiology
- From:
Chinese Journal of Hepatology
2018;26(12):940-944
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study serum HCV antibody (anti-HCV) with geographic distribution characteristics in Zhejiang Province.
Methods:A stratified random cluster sampling method was used. Serum samples of the surveyed population were collected from selected hospitals, anti-HCV antibodies were examined, then hepatitis C infection rates among different genders, regions and age groups were analyzed. The anti-HCV rate was compared using the χ 2 test.
Results:The average anti-HCV positive rate in Zhejiang Province was 0.24% [95% confidence interval (CI): 0.16% ~ 0.32%]. The antibody positive rate in the plain area was 0.32% (95% CI: 0.19% ~ 0.45%), which was significantly higher than the coastal islands 0.05%(95% CI: 0.00% ~ 0.12%, χ 2 = 7.638, P < 0.05). There was no significant difference between plain area and hilly area 0.22% (95% CI: 0.03% - 0.41%). There was no statistically significant difference in anti-HCV positive rates between males and females (χ 2 = 2.238, P = 0.135). The highest positive rate of anti-HCV (0.93%) was in the population aged 56-60 years and the lowest in the population aged less than 20 years. Anti-HCV positive rate of all age groups in 2017 was lower than that of 2006 seroepidemiological study of hepatitis C.
Conclusion:Zhejiang Province is a region with low anti-HCV positive rate and the disease prevalence further reduced than 10 years ago. The positive rate of anti-HCV in plain areas is higher than islands. Middle-aged and elderly people are the age group with high prevalence, and the anti-HCV positive rate in people under 20 years old is exceptionally low. Gender differences in anti-HCV positive rate have little effect.
