Clinical application of high mobility group box nuclear protein 1 subcomponent in the progression of liver cancer
10.3760/cma.j.issn.1007-3418.2018.11.014
- VernacularTitle: 肝癌进展中核蛋白高迁移率族蛋白超家族B族亚组分异常及其临床价值
- Author:
Zhizhen DONG
1
;
Min YAO
2
;
Wenjie ZHENG
1
;
Dengfu YAO
1
Author Information
1. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
2. Department of Immunology, Medical School of Nantong University, Nantong 226001, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
Diagnosis;
Prognosis;
Subgroup of high mobility group box family;
Molecular target
- From:
Chinese Journal of Hepatology
2018;26(11):869-872
- CountryChina
- Language:Chinese
-
Abstract:
The biological functions of high-mobility group (HMG) proteins include regulation of DNA replication, transcription, recombination and repair. According to molecular weight, sequence alignment and DNA structural characteristics, HMG proteins are subdivided into three superfamilies (HMGA, HMGB and HMGN). Recently, HMGB family members (HMGB1, HMGB2, HMGB3, and HMGB4) found to interact with hepatitis B or C virus. Therefore, activation of relevant signaling molecules to regulate transcription of genes related to hepatocellular carcinoma as a mediator of inflammation promoting HCC progression has attracted considerable attentions. This article focuses on the clinical application of the expression of HMGB family members in the process of HCC progression.
