Application of clustered regularly interspaced short palindromic repeats- associated protein 9 gene editing technology for treatment of HBV infection
10.3760/cma.j.issn.1007-3418.2018.11.012
- VernacularTitle: 成簇的规律间隔短回文重复序列及其相关蛋白9基因编辑技术在抗乙型肝炎病毒感染治疗中的应用
- Author:
Yadong WANG
1
;
Qianfei LIANG
;
Ziyue LI
;
Caiyan ZHAO
Author Information
1. Department of Infectious Diseases, the Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050035, China
- Publication Type:Review
- Keywords:
Hepatitis B virus;
Gene editing;
Covalently closed circle DNA;
Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9
- From:
Chinese Journal of Hepatology
2018;26(11):860-864
- CountryChina
- Language:Chinese
-
Abstract:
A lack of effective drugs and technical means to eradicate hepatitis B virus (HBV) is a bottleneck that limits the ability to fully cure HBV infection. Recently, genome-editing technology based on clustered regularly interspaced short palindromic repeats -associated protein 9 is an emerging technique for editing specific gene loci, which can specifically target HBV covalently closed circular DNA, effectively inhibits HBV DNA replication and regulates HBV functional protein expression, and is expected to become a powerful gene therapy tool for the complete eradication of HBV. Considering this, it has become the focus of attention for scholars at home and abroad that how to use clustered regularly interspaced short palindromic repeats -associated protein 9 to accomplish modification of HBV genomes for complete eradication of HBV. This paper summarizes the latest progress based on the latest research results at home and abroad in the application of clustered regularly interspaced short palindromic repeats -associated protein 9 gene editing technology in anti-HBV infection treatment, and expounds its potential and challenges as a radical cure for HBV infection.
