Efficacy and outcome of transcatheter closure of patent foramen ovale in patients with cryptogenic stroke
10.3760/cma.j.issn.0253-3758.2018.11.012
- VernacularTitle: 经导管封堵术治疗不明原因卒中合并卵圆孔未闭患者的临床疗效及预后
- Author:
Qiang FU
1
;
Caixia GUO
;
Lijuan DU
;
Yaqiu BAI
;
Xiping GONG
;
Yi JU
;
Jingjing LU
;
Jianke HU
;
Hui QU
;
Kehui DONG
;
Buxing CHEN
;
Yongjun WANG
Author Information
1. Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
- Publication Type:Clinical Trail
- Keywords:
Stroke;
Foramen ovale,patent;
Transcatheter closure
- From:
Chinese Journal of Cardiology
2018;46(11):882-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and outcome of transcatheter patent foramen ovale (PFO) closure in patients with cryptogenic stroke (CS).
Methods:Sixty consecutive patients with cryptogenic stroke who undertook transcatheter PFO closure between May 2015 and September 2017 in Beijing Tiantan Hospital were enrolled in this prospective study.Transcranial Doppler (TCD) bubble test was performed and right-left shunt(RLS) was confirmed in all patients.Closure success rate,effective closure rate, complications, recurrence of ischemic stroke and new onset atrial fibrillation were evaluated.
Results:A total of 60 patients (42 male,age range 24-68 (47±11)years) were included in the study.PFO size (motionless state) was (1.6±0.6)mm.RLS before closure was graded and 11 patients had moderate RLS and 48 patients had large RLS (include 41 patients who experienced shower or curtain effect).Closure success rate was 100% (60/60).No severe complications were observed.At 6 months,45 patients completed TCD bubble test.Of these, 4 patients suffered from moderate to large residual and thus effective closure rate was 91%(41/45).The mean follow-up period was 2-29 (median 12) months. During the follow-up, only 1 patient experienced recurrent cerebral infarction.New onset atrial fibrillation was not detected.
Conclusion:Transcatheter PFO closure is effective,safe and related with a good outcome in reduction of recurrent CS for patients with PFO.
