Research progress on non-coding RNAs in the molecular pathogenesis of hepatocellular carcinoma
10.3760/cma.j.issn.1007-3418.2018.10.015
- VernacularTitle: 肝癌分子发病机制中非编码RNA的研究进展
- Author:
Zhun LUO
1
;
Wei CUI
Author Information
1. Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang 110000, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
Epigenetic modification;
Non-coding RNA;
Circular RNA
- From:
Chinese Journal of Hepatology
2018;26(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer arises from chronic liver disease, and cirrhotic liver gradually develops into dysplastic nodules that eventually form malignant tumors. In recent years, molecular biotechnology development has deepened people's understanding on the pathogenesis of liver cancer. Epigenetic modifications play a significant role in DNA methylation, non-coding RNAs, chromatin remodeling, and histone modification. This review focuses on the progress of currently implicated non-coding RNAs in the molecular pathogenesis of hepatocellular carcinoma, and its potential application in improving the diagnosis and treatment.
